Hematologic Disorders

You can refer to Hematology section (Read: thalassemia, Anemia, ALL, Sickle cell anemia).
The rest is basically similar to adults.
 Neonatal polycythemia
Def
Hematocrit >65% in term infants
Nx
·       ⤴️ erythropoiesis from intrauterine hypoxia: DM, HTN, smoking; IUGR
·       Erythrocyte transfusion: delayed cord clamping; twin-twin transfusion
·       hypothyroidism or hyperthyroidism; genetic trisomy (13, 18, 21)
Clx
·       Asx (most common)
·       Reddish skin
·       ⤵️Glu – ⤴️Bilirubin
·       Respiratory distress, cyanosis,
·       Irritability, jitteriness
·       Abdominal distension
Tx
·       IV Fluid
·       Glucose
·       Partial exchange transfusion
Iron deficiency anemia in young children
RF
·       Prematurity
·       Lead exposure
·       Age < 1
     – Delayed introduction of solids (ie, exclusive breastfeeding after 6 months)
     – Cow’s, soy, or goat’s milk
·       Age > 1
     – >24 oz/day cow’s milk
     – ❤ servings/day iron-rich foods
Dx
·       Screening hemoglobin at age 1
·       Hemoglobin <11 g/dL, ⤵️ MCV, ⤴️RDW
Tx
·       Empiric trial of iron supplementation
 Avascular Necrosis
Causes
·       SLE
·       Sickle cell anemia
·       Osteomyelitis
Steroids
Clx
·       Groin pain on weight bearing
·       Pain on hip abduction & internal rotation
·       NO erythema, swelling, point tenderness
Labs
·       ⓝ WBCs / ESR & CRP
Imaging
·       MRI

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