Hemiglobinopathy

 Methoglobenemia
Drugs
– Dapsone,
– Nitrates
– Benzocaine
S/S
– Bluish discoloration
– Hypoxemia
If things go severe (>50% of Hgb): SZ, AMS, Resp Depression.
Dx
-Pulse oximetry: -85%02
-ABG: false ⤴️ Pa02
-(Large 02 Gap)
Tx
D/C drug  + Methylene Blue
Porphyria Cutanea Tarda
S/S
·       Mainly skin Sx
·       Blisters,
·       Hypopigmentation/hyperpigmentation on sun-exposed areas
·       Scarring and calcification
Associations
·       Hep C
·       Alcoholic
·       Estrogen
·       Smoking
Dx
·       Mild ⤴️ LFTs
·       Iron ⤴️
·       ⤴️ plasma or urine porphyrin levels

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