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Hodgkin
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Non-Hodgkin
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Path
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· B-Cell Lymphoma
· Associated w/ EBV
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· B-Cell Lymphoma
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S/S
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· LN ⊕
· Constitutional Sx (caused by cytokines from RS cells)
· They can have SVC syndrome
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· LN ⊕
· Constitutional Sx
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Types
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· Nodular Sclerosing
· most common
· 👩🏻 predominance
· lymphocyte-rich
· especially in < 35 yo
· lymphocyte-depleted
· especially in > 60
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· diffuse B-cell lymphoma
· Burkitt lymphoma
· follicular lymphoma
· marginal zone lymphoma
· mantle cell lymphoma
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Dx
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· LN Bx
· Reed-sternberg cells
· CD 15 – 30
· Imaging for staging
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· LN Bx
· CD 20
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Tx
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· Local: excision
· Anyone w/ Constitutional Sx | Late stage:
· ABVD Regimen
· Adriamycin (doxorubicin)
· Bleomycin
· Vinblastine
· Dacarbazin
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CHOP:
· Cyclophosphamide
· Hydroxydaunorubicin
· Vincristine
· Prednisone
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