Nephrology Disorders

 UTI in children 👶🏼
RF
·       Female
·       Uncircumcised male
·       VI-JR, anatomic defects
·       Dysfunctional voiding
·       Constipation
Clx
·       Dysuria
·       Fever
·       Suprapubic pain (cystitis) &/or flank/back pain (pyelonephritis)
Labs
·       Pyuria
·       Bacteriuria on urine culture
Tx
·       Antibiotic therapy (1-2 weeks w/ 3rd-gen cephalosporins)
·       If VCUG

VUR

  • Dx? Voiding cystourethrography
  • Tx:
    • Nonsurgical vs surgical
    • Primary –> may resolve on its own –> medical
    • Secondary –> can be anatomical / functional
      • Anatomical –> Surgery
      • Functional –> tx underlying cause

Posterior urethral valves

  • most common reason for a newborn boy not to urinate during the first day of life (meatal stenosis should also be looked for).
  • Catheterization can be done to empty the bladder (the valves will not present an obstacle to the catheter).
  •  Voiding cystourethrogram is the diagnostic test,
  • Tx: and endoscopic fulguration or resection will get rid of them.

Obstructive uropathy

  • def? obstruction of urinary tract, by any cause, that leads to back flow and hydronephrosis
  • in peds, mcc is birth defects
  • Dx:
    • Palpable abdominal mass in newborn; most common cause is hydronephrosis
    • Obtain VCUG in all cases of congenital hydronephrosis and in any with ureteral dilatation to rule out posterior urethral valves
  • Causes
    • MCC –> uretropelvic obstruction
    • Important cause –> posterior urethral valve –> ⤴️ risk for ESRD
  • Tx:
    • Decompress bladder + IV Abx / vesicostomy

Nephrotic syn

  • Steroid-sensitive MCDz is MC nephrotic syn in peds.
  • Dx: UA –> proteinuria

Minimal Change Dz:

  • Tx:  prednisone for 4–6 w, then taper 2–3 months w/o bx
    • Restrict Na
    • If severe: IV albumin + diuretics
  • Bx? if HTN/hematuria/HF, or if steroid-resistant (u tx for 8 weeks, no response)
  • Complications
    • Infections –> check vaccinations! (pneumococcus, varicella, PPD)
    • MC infection –> spontaneous peritonitis (s.pneumonia)
    • Thromboembolism
  • Prognosis: most have episodes of relapses, but they ⤵️ w/ age.

Torsion

  • PEx? No cremastric reflex (torsion tears the relfex)
  • Dx: Doppler flow U/S (only to determine direction of torsion and to guide manual detorsion, if urologist decides this is warranted; also to confirm successful detorsion in a completely asx px)
  • Tx: emergent surgery

Epididymitis

  • After puberty – sexual active
  • Pain + scrotal swelling –> UA shows pyuria –> Tx w/ Abx

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