Sepsis

 Sepsis
Def
·       a dysregulated host response to infection that results in organ dysfunction
·       can go to septic shock
RF
·       admission to ICU
·       bacteremia
·       advanced age (≥ 65 years of age)
·       immunosuppression
·       diabetes
·       obesity
·       malignancy
S/S
·       Fever
·       Sx of infection source
·       Sx of organ failure (liver / kidney)
·       AMS + RR >30 + BP ⤵️
·       Warm flushed skin
Dx
·       leukocytosis or leukopenia
·       elevated C-reactie protein
·       arterial hypoxemia
·       acute oliguria and worsening creatinine
·       elevated lactate
·       respiratory alkalosis with a metabolic acidosis 
·       thrombocytopenia
·       hyperbilirubinemia
Tx
·       ICU Admission
·       Remove source of infection if found (Catheter)
·       IVF
·       IV Abx – administered preferably within the first hour once a presumed diagnosis of sepsis has been made
Comp
·       DIC
·       Death
·       Multi-organ failure

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