Nephrotic Syndrome

Nephrotic
Syndrome
·       Sx: proteinuria + ⤵️ Albumin + Edema + hyperlipidemia + frothy urine
·       Dx:
o   Labs: hypoalbuminemia + hyperlipidemia
o   U/A: r/o orthostatic proteinuria + check for massive proteinuria >3.5 g/day
MCD
·       MCC in peds
·       No bx except if steroid-resistant
·       May follow recent infection, immunizations, or may be idiopathic
·       Steroid
FSGS
·       Can be d/t: HIV, SCD, heroin abuse, interferon treatment
·       Bx: focal segments of sclerosis
Tx U/C
Steroids
Membranous
nephropathy
·       Immune-complexes –> complement
·       Subepithelial + spikes and domes
·       Caucausians
·       can be 2˚ to SLE / Meds / Hep B+C / gold
steroids and cyclophosphamide
Amyloidosis
·       many other sx
·       apple-green birefringence on Congo red stain under polarized light
·       RA / MM
tx undelying cause
DM
·       Bx: expansion of the mesangium+ Kimmelstiel-Wilson lesions
Tx: ACEIs / ARBs
AIDS Nephropathy
(Focal glomerulosclerosis)
·       w/ AIDS
usually will need dialysis
HTN Nephropathy
·       Diffuse glomerular sclerosis
·       Longstanding severe HTN
Tx HTN

Causes of nephrotic syndrome
Focal segmental glomerulosclerosis
African American & Hispanic ethnicity; obesity;
HIV & heroin use
Membranous nephropathy
Adenocarcinoma (breast, lung); NSAlDs; Hep B; SLE
Membranoproliferative glomerulonephritis
 Hep C & B
Minimal change disease
NSAlDs; lymphoma
lgA nephropathy
URTI
Minimal change disease
#
• Most cornrnon cause of nephrotic syndrome in children
• Median age 2-3; 85% of cases occur before 10 years of age
Path
• T-cell mediated injury to podocytes causes ⤴️ molecular permeability to albumin
• Majority of cases are idiopathic
Clx
• Fatigue
• No hematuria
• Edema
Dx
• Proteinuria
• Hypoalburninernia
• Renal biopsy w/o microscopic changes
Tx
Corticosteroids

Nephritic Syndrome

Nephritic
Syndrome
·       Sx: Hematuria + HTN + oliguria + azotemia
·       Dx: U/A (Dysmorphic RBCs / RBCs casts)
·       Bx is needed for definitive dx
·       Tx: steroids + cyclophosphamide
PSGN
·      T3 hypersensitivity
·      2-3 weeks after a streptococcal infection
·      ASO titer
Tx: nothing, self-resolves
Loop diuretics for HTN
Rapidly progressive GN
·       Bx: Crescent shape
·       Goodpasture (Lung + Kidney)
·       T2 hypersensitivity
·       Anti-BM Abs
·       Wagner granulomatosis (Nose + lung + kidney)
·       C-Anca
steroids + cyclophosphamide
IgA nephropathy
·       presents during the infection
·       Bx: mesengial proliferation
Tx: ACEI for HTN
Alport
·       Eyes + SN hearing loss + Kidney
·       Collagen type IV
Can’t Tx it.
MPGN
·       can be both: nephrotic + nephritic
·       Hep B + C / Nephritic factor
Tx underlying condition

Henoch-Schönlein purpura
Path
IgA-mediated leukocytoclastic vasculitis
S/S
·       Palpable purpura
·       Arthritis/arthralgia
·       Abdominal pain,
·       Intussusception
·       Renal disease similar to IgA nephropathy
Dx
PLT & coagulation studies
to ⤴️ Cr
Hematuria ± RBC casts ± proteinuria
Tx
·       Supportive (hydration & NSAlDs)
·       Hospitalization & systemic glucocorticoids in pts with severe symptoms
PSGN
Clx
Happens 2 weeks post-infection
Can be Asx
__
If Sx:
-Gross hematuria (tea- or cola-colored urine)
-Edema (periorbital, generalized)
-HTN
Dx
UA: protein, blood, RBC casts
Serum:
·       ⤵️ C3 & C4
·       ⤴️ Cr
·       ⤴️ Anti-DNase B& T AHase
·       ⤴️ ASO & anti-NAD (from preceding pharyngitis)
Tx
Supportive
sx goes within weeks, labs take months to return
IgA Nephropathy
PSGN
Clx
·       Usually w/i 5 days of URTI
·       More common in young men
·       Rx gross hematuria
·       10-21 days post streptococcal infection (pharyngitis)
·       Gross Hematuria
Dx
·       Cr
·       Bx: Mesengial IgA deposits
·       ⤵️ C3 & C4
·       ⤴️ Cr
·       ⤴️ Anti-DNase B& T AHase
·       ⤴️ ASO & anti-NAD
·       Bx: subepithelial humps
Prog
benign
benign
Alport syndrome
Path
·       Inherited (most commonly X-Iinked)
·       Mutation of type IV collagen
Clx
Nephropathy
·       Hematuria (microscopic or gross)
·       Progressive renal insufficiency
·       Proteinuria
·       Hypertension
SN hearing loss
Anterior lenticonus (lens protrusion)
Dx
Molecular genetic testing
Renal bx: longitudinal splitting of GBM

Calcium

⤴️

Milk-alkali syndrome
Path
·       Excessive intake of calcium & absorbable alkali
·       Renal vasoconstriction & decreased GFR
·       Renal loss of sodium & water, reabsorption of bicarbonate
S/S
 N/V
Constipation
Polyuria/Polydipsia
Neuropsychiatric
Dx
⤴️ Ca
Metabolic alkalosis
AKI
PTH
Tx
 IVF
D/C Causative agent
Tx of Hypercalcemia
Severe
>14
Immediate
·       IVF + calcitonin
·       Avoid loop diuretics unless volume overload (heart failure) exists
Long-term: Bisphosphonate
Sxic
Moderate
Usually no immediate treatment required unless sx
If Sxic → Bisphosphonate
Asx / Mild
<12
·       No immediate treatment required
·       Avoid thiazide diuretics, lithium, volume depletion & prolonged bed rest
⤵️
Acute Hypocalcemia
Causes
·       Neck surgery (parathyroidectomy)
·       Pancreatitis / Sepsis
·       Tumor Lysis syndrome
·       Acute alkalosis
·       Chelation: blood transfusion (Citrate),
·       EDTA, foscarnet
Clx
Muscle cramps
Chvostek & Trousseau signs
Paresthesias
Hyperreflexia (⤴️  DTR) / Tetany
SZ
Tx
IV calcium gluconate/chloride

Sodium

 Sources: MTB / OME / UW
Hypernatremia

Hyponatremia
 
 Osmolality
Volume
Urine
Cause
Low
<275
⤵️
Na <40
Salt loss (Vomiting, Diarrhea, Dehydration
Na >40
RENAL SALT LOSS (Diuretics? Adrenal insufficiency?)
Osm <100
Psychogenic Polydipsia
Osm >100
SIADH
⤴️
ø
CHF / Hepatic failure / Nephrotic Syndrome
ø
Pseudohyponatremia (⤴️ Lipids, Proteins)
High >295
Hyperglycemia
Mild
Moderate
Severe
Asx
Minimal confusion
Coma, Sz
Restrict fluids
Saline / Loop diuretics
HYPERTONIC SALINE
SIADH
?
·       CNS insult of any kind
·       Medications (Carbamazepine, SSRIs, NSAIDs)
·       Lung disease (PNA)
·       Ectopic ADH secretion (SCLC)
S/S
·       Hyponatremia: Severe: SZ, coma, AMS
·       Euvolemia (Moist mucous membranes, no edema, no JVD)
Dx
·       Hyponatremia
·       Serum osmolality <275 (hypotonic)
·       Urine osmolality >100
·       Urine sodium >40
Tx
Fluid restriction ± salt tablets
Hypertonic (3%) saline for severe hyponatremia
Iatrogenic Hyponatremia
RF
·       Hypotonic fluid hydration
·       Children, premenopausal women, elderly
·       Hypoxia
·       CNS Disorders
S/S
·       Headache
·       N/V
·       Encephalopathy (AMS, SZ)
Tx
·       Hypertonic (3%) saline
·       Serial measurement of electrolytes
·       Increase serum sodium 6-8 in first 24hrs

Stones

Source: OME 
Types
Common types of kidney stones:
Type
Pt
Radio
Crystal shape
Calcium
(oxalate, phosphate)
>75% of stones
·       ⤴️PTH
·       High-sodium, high-oxalate diet
·       Malabsorption (oxalate)
·       Renal tubular acidosis (phosphate)
·       Small
·       Radiopaque
·       Octahedron or envelope (oxalate)
·       Wedge or rosette (phosphate)
MAP
(Struvite)
·       Upper tract infection with urease-producing organisms (e.g., proteus)
·       Large
·       Radiopaque
·       Rectangular/prism
Uric acid
5%-8% of stones
·       Gout
·       Diabetes/ metabolic syndrome
·       Myeloproliferative disorders
·       Small
·       Radiolucent
·       Yellow/brown
·       Rhomboidal

Struvite (MAP) stones
RF
Rx upper UTI
Urease-producing 👾 (Klebsiella, Proteus)
Path
Hydrolysis of UREA → Ammonia:
         Urea → NH3 + C02
         NH3 + H2O → NH4 + OH-
⤴️ Urine pH
Precipitation of Magnesium Ammonium Phosphate salts
Clx
·       Large staghorn calculi
·       Fever, mild flank pain due to infection
·       Obstruction of collecting system
·       ATROPHY of renal parenchyma
Tx
Surgical Resection & Abx
Uric Acid kidney stones
RF
·       ⤴️ Uric acid excretion: Gout, myeloproliferative disorders
·       ⤴️ urine concentration: Hot, arid climates; dehydration
·       ⤵️  urine pH: Chronic diarrhea (Gl bicarbonate loss), metabolic syndrome/DM
Path
·       Acidic urine favors formation of uric acid (insoluble) over urate (soluble)
·       Supersaturation of urine with uric acid precipitates crystal formation
Clx
·       Radiolucent stones (not visible on x-ray)
·       Uric acid crystals on urine microscopy
·       Urine pH usually <5.5
Tx
Alkalinization of urine (potassium citrate)
Tx:
Prevention of rx stones
Dietary
• Increase fluids (produce >2L urine/day)
• Reduce sodium (<100 mEq/day)
• Reduce protein
• Normal calcium intake (1200 mg/day)
• Increase citrate (fruits & vegetables)
• Reduced-oxalate diet for oxalate stones (dark roughage, vitamin C)
Drugs
• Thiazide diuretic
• Urine alkalinization (potassium citrate/bicarbonate salt)
• Allopurinol (for hyperuricosuria-related stones)

Urinary Retention/Incontinence

Urinary Retention
Acute:
·       BPH
·       It is often precipitated during a cold, by the use of antihistamines and nasal drops, and by abundant fluid intake.
·       The patient wants to void but cannot, and the huge distended bladder is palpable.
·       Tx: An indwelling bladder catheter needs to be placed and left in for at least 3 days.
o   First line of long-term therapy is alpha-blockers, the most selective of which is tamsulosin.
o   5-Alpha-reductase inhibitors, like finasteride or dutasteride, are used for very large glands (more than 40 g).
o   TURP remains the final surgical option for benign prostatic hypertrophy.
Post-op
·       This is gonna be overflow incontinence
·       Pt will complain of small amount of urine
·       Distended bladder
·       Tx: urethral catheter
Urinary Incontinence
Type
Pathogenesis
S/S
Dx
Tx
Stress
increased urethral mobility 
·       Urinary incontinence with ↑ intra-abdominal pressure
·       e.g., coughing, sneezing, laughing, and physical exertion
·       No urine loss at night
·       cystocele may be present
·       Q-type test*
·       1˚ Kegel exercises
·       Topical estrogen for post-menopausal women
·       Pessary
·       Midurethral sling in patients unresponsive to initial therapy and pessary
Urge
·       Detrusor muscle overstimulation
·       Frequent urinary leakage
·       also occurs at night
·       disrupts sleep
·       Urge to urinate and may be unable to reach the bathroom in time
·       Urodynamic testing
·       Antimuscarinics (oxybutynin)
·       Mirabegron
Overflow
·       Incomplete bladder emptying results in urinary leakage 2˚ to
detrusor muscle underactivity
·       age, diabetes mellitus, and multiple sclerosis
·       bladder outlet obstruction
·       fibroids and benign prostatic hyperplasia
·       Urine loss without warning or triggers
·       Post-void residual volume measurements ⤴️
·       Urodynamic testing
·       Clean intermittent catheterization 
Mixed Incontinence
·       Symptoms of both stress and urge incontinence
·       Life style modifications and pelvic floor exercises is first-line
·       If unresponsive to first-line treatments then therapy is based on the predominant symptoms
Vesicovaginal fistula
·       Fistula that forms creating a connection between the bladder and vagina
·       May be secondary to surgery, pelvic irradiation, malignancy, or prolonged labor
·       Painless, continuous leakage of urine from vagina
·       Fluid pooling in the vagina
·       You put methylene blue in bladder, then the tampon in vagina is blue
·       Surgery
Stricture
narrowing
sx of overflow + obstruction + rx UTI
Surgery (ballon)
 Urinary incontinence
Stress
Leakage with Valsalva (coughing, sneezing, laughing) 
·       Lifestyle modifications
·       Pelvic floor exercises
·       Pessary
·       Pelvic floor surgery
Urgency
Sudden, overwhelming, or frequent need to void
·       Lifestyle modifications
·       Bladder training
·       Antimuscarinic drugs
Mixed
Features of stress & urgency
·       1˚ Diary of voiding
·       Tx based on dominant type
Overflow
Constant, involuntary dribbling & incomplete emptying
·       Identify & correct U/C
·       Cholinergic agonists
·       Intermittent self-catheterization
Urethral stricture (Narrowing ><)
Cause
·        👨🏻 > 👩🏻
·       Urethral trauma (catheterization)
·       Urethritis
Sx
·       Weak or spraying stream
·       Incomplete emptying
·       Irritative voiding (Dysuria, frequency)
Comp
·       Acute urine retention
·       Rx UTIs
·       Bladder stones
Dx
·       Postvoid residual, uroflowmetry
·       Urethrography
·       Cystourethroscopy
Tx
Dilation / Urethroplasty

Penis, Testes & Bladder

 Varicocele
Clx
Soft scrotal mass (“bag of worms”)
·       ⤵️ In supine position
·       ⤴️ With standing/Valsalva maneuvers
Subfertility
Testicular atrophy
US
·       Retrograde venous flow
·       Tortuous, anechoic tubules adjacent to testis
·       Dilation of pampiniform plexus veins
·       Does not transluminate
Tx
Gonadal vein ligation (boys & young men with testicular atrophy)
Scrotal support & NSAlDs (older men who do not desire additional children)
 Testicular Cancer
#
Age 15-35
RF
FHx, cryptorchidism
Germ cell (95%): seminomatous or nonseminomatous (embryonal carcinoma, yolk sac, choriocarcinoma, teratoma, mixed)
Sex cord-stromal tumors: Sertoli cell / Leydig cell
Sx
painless testicular mass
Dull ache in lower abdomen
Dx
Examination: firm, ovoid mass
⤴️ tumor markers (AFP, ß-hCG, LDH)
Scrotal US
Testicular Torsion
#
Most common in adolescents
S/S
·       Testicular, inguinal, abdominal pain
·       N/V
·       Horizontal testicular lie with elevated testicle
·       Absent cremasteric reflex
·       Swollen, erythematous scrotum
US
No blood flow on scrotal with Doppler
Tx
·       Surgical detorsion & fixation with exploration of the contralateral side
·       Manual detorsion (if immediate surgery is not available)
Testicular Hematoma
Hx: TRAUMA
Sx: rapidly expanding hematoma
Complications: Compartment syndrome
Dx: US
Tx: Surgical Evacuation
Indications for Cystoscopy
Gross hematuria with no evidence of glomerular disease or infection
Microscopic hematuria with no evidence of glomerular disease or infection but increased risk for malignancy
Recurrent UTIs
Obstructive sx w/ suspicion for stricture, stone
Irritative sx w/o urinary infection
Abnormal bladder imaging or urine cytology
Emergencies
Torsion
Epididymitis
·       Acute spontanous pain
·       Young
·       Horizental lie
·       Pain w/ elevation + no reflex
·       Dx: US w/ Doppler (no blood flow)
·       Tx: Bilateral Orchiopexy
·       Acute spontanous pain
·       Young (gono & chlamydia) vs Old: E.coli
·       vertical lie
·       NO Pain w/ elevation
·       FEVER
·       Dx: US w/ Doppler (positive blood flow) –> UA + Urine Cx
·       Tx: Abx (depends on age).
Pyelo
Prostatits
·       Sick pt
·       FEVER, CHILLS
·       FLANK Pain
·       Dx: UA + Cx + US
·       Tx: Hospitalize + IV Abx
·       Sick pt
·       FEVER, CHILLS
·       DRE: tender prostate
·       NEVER EVER MY FUCKING BROTHER DO DRE AFTER Dx. (induces sepsis)
·       Dx: UA + Cx + US
·       Tx: IV Abx

Chronic Kidney Disease

CKD Stages
Stage 
Features
GFR
Tx
1
 No effect on GRF
>90
Tx Underlying conditions (DM, HTN, etc)
2
 Mild
>60
Tx Underlying conditions (DM, HTN, etc)
3
 Moderate
>30
Tx Underlying conditions (DM, HTN, etc)
4
 Severe
>15
Prepare for dialysis
5
Kidney Failure
<15
Dialysis
Complications of CKD
Goal
Tx
Anemia
 Hgb >10
Iron / EPO
Osteoporosis
 DEXA >-2.5
Ca / Vit D
2˚ HyperPTH
 Normal Ca
Calcimimetics
Phosphate binders
Volume overload
 ø
Diuretics
Metabolic Acidosis
Bicarbonate >20
Sodium Bicarbonate

Acute Kidney Injury

Prerenal AKI
Path
⤵️ Renal perfusion
·       HYPOvolemia (Trauma/Surgery)
·       Effective Arterial Blood Volume (eg, heart failure, cirrhosis)
·       3rd-Spacing (eg, sepsis, pancreatitis)
·       RAS
·       Afferent arteriole vasoconstriction (NSAIDs)
Dx
·       ⤴️ Cr (50% from baseline)
·       ⤵️ Urine Output
·       BUN/Cr ratio >20:1
·       Fractional excretion of sodium <1%
·       Unremarkable (“bland”) urine sediment
Tx
 IVF

Extremely HY
Muddy brown casts
ATN
Hyaline casts
Prerenal azotemia
RBC casts
GN
Fatty casts
Nephrotic
Waxy/broad casts
CKD
WBC Casts
Intersitial nephritis (Eø) / pyelonephritis
HY: how to ddx different causes of ATN?
·       Drugs take time to cause ATN (gentamicin can cause ATN)
·       Rhabdo should have ⤴️ CPK (>5000) + Urine dip for heme.
·       prolonged Hypotension (MCC).
Crystal-induced AKI
?
·       Acyclovir
·       Sulfonamides
·       Methotrexate
·       Ethylene glycol
·       Protease inhibitors
·       Uric acid (tumor lysis syndrome)
Clx
·       Usually Asx
·       AKI 67 days of starting drug
·       UA: Hematuria, pyuria & crystals
·       ⤴️ risk with volume depletion, CKD
Tx
·       Discontinuation of drug
·       Volume repletion
·       Loop diuretic
Acute Interstitial Nephritis
Causes
Drugs (penicillins, TMP-SMX, cephalosporins, NSAIDS)
Clx
·       Maculopapular rash
·       Fever
·       New drug exposure
·       +/- Arthralgias
Lab
·       AKI
·       Pyuria, hematuria, WBC casts
·       Eosinophilia
·       Renal Bx: Inflammatory infiltrate
Tx
D/C offending drug / Systemic glucocorticoids
Contrast-induced nephropathy
RF
Age >75
CKD (especially diabetic nephropathy)
Reduced renal perfusion (d BP)
Causes
ATN: Direct cytotoxicity
Pre-renal: Renal vasoconstriction (FENA <1 %), even in the absence of clinical volume depletion
Prevention?
IVF
Use lowest volume of contrast
Hold NSAlDs
Clx
Patients with Contrast-induced Nephropathy show ⤴️ Cr
w/i 24-48 hours then return to .